Osteopathy Articles and Abstracts

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Contribution to the casuistics of osteopathy in Minkowski-Chauffard anemia. Clinical and pathogenetic considerations.
Zucchi, V. (1961), Progr Med (Paris) 17: 21-8.

Contribution to the knowledge of "Camurati-Engelmann osteopathy".
Cozzolino, A. (1959), Arch Ortop 72: 976-89.

Controlling renal osteopathy with keto acids
Schmicker, R., P. T. Frohling, et al. (1984), Z Urol Nephrol 77(11): 661-70.
Abstract: Starting from the results of former investigations the influence of the long-term treatment with the KA of the essential amino acids on the renal osteopathy is investigated. For this purpose we compared 27 patients with renal insufficiency (serum creatinine 981 +/- 354 mumol/l), who besides vitamin D had been treated with KA for at least 12 months, to a group of 50 patients (serum creatinine 778 +/- 273 mumol/l), who had received vitamin D over 19 +/- 9 months, and to a control group of 27 patients (serum creatinine 928 +/- mumol/l) without an adequate conservative therapy. While the control group showed the typical constellation in advanced renal insufficiency with hypocalcaemia, hyperphosphataemia, clearly increased PTH levels, clearly increased CT values and normal 25-OH-D concentrations, during the diettherapy and the vitamin D substitution a significant increase of the serum levels of calcium, 25-OH-D and CT as well as a significant decrease of the PTH and the anorganic phosphate in the serum developed. Under the combination therapy with KA and vitamin D despite the reduction of the phosphate binders another significant decrease of the PTH and the anorganic phosphate was observed. The mineral content of the bones was within the normal in the two therapy groups. The percentage of the normal histological findings of the bones was with 40.7% highest despite the advanced renal insufficiency in the simultaneous substitution with KA. While in the vitamin D group during the control biopsy after 12 months in 20.5% of the cases an improvement of the histological findings developed, this effect occurred under additional KA-therapy in 51.9% of the cases. The results allow the conclusion that by means of the long-term treatment with KA a favourable influence on the renal osteopathy develops.

Cooley's hemo-osteopathy in adults.
Vallario, V. and G. Rosa (1962), Arch Ortop 75: 989-1001.

Cranial osteopathy, delusion or reality?
Ferre, J. C., C. Chevalier, et al. (1990), Actual Odontostomatol (Paris) 44(171): 481-94.
Abstract: After having outlined the theories of cranial osteopathy (SUTHERLAND, KARNI, UPLEDGER, and, more recently, CLAUZADE and DARRAILLANS), the authors refute the latter point by point. "Primary respiration" is in fact a way of thinking, and the various bones making up the calvaria and base of the skull, which are solidly synostosed in the adult, are clearly incapable of the pretended rhythmic displacements "described" by the osteopaths. Moreover, the C.R.L., like any liquid, is incompressible and mildly pulsatile. Conversely, although the brain clearly shows rhythmic pulsations, which every neuro-surgeon notes every day, the latter are exclusively connected to the vascular system.

Densitometric studies by means of the photon absorption technic in renal osteopathy
Samizadeh, A., H. Loew, et al. (1978), Verh Dtsch Ges Inn Med(84): 1113-5.

Detection of thyreogenic osteopathy with the aid of the modern photon absorption technic
Bekier, A. (1975), Schweiz Med Wochenschr 105(10): 304-7.
Abstract: 163 male and female patients with confirmed metabolic status of the thyroid have been investigated with the aid of the 125-J photon absorption technique ("Bone Analyzer"). In the normothyroid group pathologically low values were found in 14.6 percent of cases. Findings which fell below a standard deviation of the normal range were regarded as pathologic. In 42 male and female patients with confirmed thyroid hyperfunction and decompensated autonomous adenomas, mineral content measurements in the radius revealed pathological values in 28.5 percent.

Diabetic osteopathy (an analysis of 37 cases)
Wang, X. Y. (1989), Zhonghua Fang She Xue Za Zhi 23(1): 31-4.
Abstract: This paper reported the result of clinicoradiologic analysis of 37 patients with diabetic osteopathy. The site of predilection was the bony ends of the extremities, especially the foot (91.9%). The main clinical manifestation was the presence of a non-healing chronic ulcer, whereas diabetic gangrene of bone constituted the chief x-ray finding, which was characterized by osteolytic destruction at the bony ends of metatarsals and phalanges, with minimal periosteous reaction if any. The bony articular surfaces were usually preserved. The chief distinction to be made is osteomyelitis. The mechanism of diabetic osteopathy is most probably systemic metabolic disorders resulted from disturbance of carbohydrate metabolism with secondary neurovascular changes. Infection probably plays the role of enhancing effect in gangrene of bone.

Diabetic osteopathy of the foot
Lorenz, R. and G. Friedmann (1982), Radiologe 22(9): 419-22.

Diabetic osteopathy. 4. Laboratory findings
Kocian, J. and J. Brunova (1990), Vnitr Lek 36(5): 460-6.
Abstract: The authors investigated in a group of 38 subjects with type I diabetes and 222 subjects with type II diabetes laboratory values indicating the level of bone metabolism: calcium, phosphorus, alkaline phosphatase activity in serum, urinary calcium excretion, and they compared the values mutually and with the level of bone mineralization. The authors found significantly lower serum calcium values in all investigated groups, the lowest ones in women with type II diabetes. To these values corresponded always reduced values of bone mineralization which were also lowest in women with type II diabetes. The very lowest bone mineralization was found in groups of subjects treated with oral antidiabetics, the values in women being lower than in men. The authors found also a higher alkaline serum phosphatase activity, in particular of its bone isoenzyme. The significant correlation between the reduced serum calcium value and bone mineralization indicates that this laboratory value has a decisive influence and importance in the development of osteoporosis. The high alkaline phosphatase activity suggests that there is also prescut osteomalacia.

Diabetic osteopathy. 5. Prevention
Kocian, J. (1990), Vnitr Lek 36(7): 693-8.
Abstract: The author presents an account on possibilities of prevention of osteoporosis and osteomalacia in diabetics by eliminating or reducing some causes which lead to these complications. In osteoporosis this involves a modified diabetic diet, burdening of the bones by suitable exercise, compensation of diabetes and screening and treatment of complications of diabetes. Prevention of osteomalacia in diabetics includes according to the author adequate exposure to ultraviolet rays which ensures an adequate amount of vitamin D in the skin, dietary measures and administration of vitamin D, treatment of complications of diabetes and methods of mobilization of the patients.

Diabetic osteopathy. Favorable effect of treatment of osteomalacia with vitamin D and calcium on high blood glucose levels
Kocian, J. (1992), Vnitr Lek 38(4): 352-6.
Abstract: A group of 61 diabetics (incl. 35 treated by diet alone and 26 who were treated also by oral antidiabetics) with associated osteomalacia were treated with vitamin D (dosage 42,000 to 85,000 i. u. per day) and calcium (470-700 mg/day). After six weeks of this treatment the serum calcium level rose on average by 0.15 mmol/l and the blood sugar level declined on average by 1.68 mmol/l. A linear negative correlation was proved between these two parameters. The fasting blood sugar level declined in 53 subjects (86.88%) and only in five patients (8.19%) the blood sugar level increased, in three subjects (4.91%) it did not change. Possible explanations of this phenomenon include the influence of an increased calcium concentration on insulin secretion and release from pancreatic beta-cells on the one hand and enhanced glucose utilization in the periphery on the other hand.

Diabetic osteopathy. I.
Kaniak, J., Z. Knapik, et al. (1965), Pol Arch Med Wewn 35(7): 1037-42.

Diabetic osteopathy. Prospective study
Licea Puig, M., A. Lapinet Estrada, et al. (1982), Rev Clin Esp 167(4): 253-6.

Diabetic osteopathy
Goliat, E. A. and K. Ostrowski (1997), Pol Arch Med Wewn 97(2): 161-9.

Diabetic osteopathy
Kaniak, J., A. Giermanski, et al. (1977), Pol Tyg Lek 32(8): 321-3.

Diabetic osteopathy
Otto-Buczkowska, E. (1995), Wiad Lek 48(1-12): 122-4.

Diagnosis & therapy of osteopathy of renal tubular origin in adults.
Jesserer, H. (1959), Wien Klin Wochenschr 71(16): 277-80.

Diagnosis and treatment of osteopathic parathyroid adenoma
Xu, H. Z., Y. Li, et al. (2003), Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 17(6): 446-9.
Abstract: OBJECTIVE: To introduce the advanced diagnostic technologies and share the surgical experience of parathyroid adenoma. METHODS: From November 1986 to August 2000, 9 patients with parathyroid adenoma who underwent operations were analyzed retrospectively. Out of them, there were 3 males and 6 females and their ages ranged from 12 to 55 years with an average of 32 years. The average disease course was 4 years and 9 months. General decreased density of the bone cortex and subperiosteum absorption were found in all 9 cases, while multi bone cyst lesion in 3 cases; obsolete fracture in 5 cases, including 2 cases of nephrolithiasis. Before operation, one child bore claudication and the other 8 patients suffered from disability. Serum parathyroid hormone (PTH) level increased markedly in 5 patients examined (633.87-1,017.40 pmol/L, normal value: 28.50-90.50 pmol/L). Radionuclide scan showed that imagings of parathyroid adenoma appeared in 3 patients. RESULTS: Parathyroid adenoma was resected via neck approach in 7 cases, and by way of sternum in the other 2 of the adenomas located in the chest. Parathyroid adenoma was diagnosed pathologically in 9 cases. All the 9 patients had no relapse during the 2-16 years of follow-up, with apparent relief of ostealgia and the normal serum PTH level, and roentgenogram showed fracture healing, great alleviation of the osteopathia. CONCLUSION: PTH examination as an advanced technique plays an important role in the differential diagnosis of hypercalcaemia. Color Doppler and radionuclide scan can locate the lesion. It is vital to judge the nature of the lesion by naked eyes, while frozen slices serves as a necessity to confirm. Enough parathyroid tissue should to be remained to assure normal parathyroid function. The variable number and ectopic possibility of parathyroid glands should be considered. Both the short-term and long-term surgical outcome of parathyroid adenoma are satisfactory.

Diagnosis of osteopathy caused by antiepileptic drugs
Baars, A., M. Baars, et al. (1981), Z Arztl Fortbild (Jena) 75(15): 687-90.

Diagnosis of osteopathy in cattle using bone biopsy
Marek, J. and J. Meisl (1985), Vet Med (Praha) 30(8): 457-65.
Abstract: Seventy samples of bone bioptates from 70 cows were examined by the biochemical analysis and radiographically. By biochemical examination of bone bioptates taken from the tuber coxae we demonstrated the osteoporotic process in 87% of examined dairy cows, the osteomalacic process in 57% and the combined form, i.e. osteoporosis/osteomalacia in 51.4% of examined dairy cows. According to the distribution of findings in relation to the phases of reproduction cycle, the frequency of pathological findings was found to be highest in cows after calving. The examination of ash for the content of osteotrophic minerals, calcium and phosphorus, has demonstrated the physiological relation in 5.7% of dairy cows only, widened ratio in 87.2% and reduced one in 7.1% of dairy cows. By a comparison of the biochemical finding with the radiographic one we have revealed the difference, by 23% lower, in identification of pathological cases by the radiographic method. The method of radiographic examination of bone bioptates can be used as screening in the diagnostics of metabolic osteopathies.

Diagnosis of renal osteopathy
Schulz, W. (1978), Dtsch Med Wochenschr 103(51): 2023-5.

Dialysis osteopathy with spontaneous fractures, progressive demineralization and therapy resistance
Koall, W. and V. Luci (1983), Z Gesamte Inn Med 38(18): 481-8.
Abstract: In 25 (33.8%) of 74 chronically haemodialysed patients a distinct osteopathy with bone pain, spontaneous fractures, arthralgias and weakness of the muscles due to dialysis was present. In comparison to a group without complaints the duration of the dialysis was longer by 6 months, the mineral contents of the bones was decreased in 38%, in the comparative group in 22%. A progressive demineralisation was found in 46%, in the comparative group in 20%. Hypercalcaemias under vitamin D2 caused a therapy resistance. In 1 exemplary case (type IIc, PTH 0.3 micrograms/l) in the 3rd year of dialysis a fracture of the neck of the femur took place and an endoprosthesis was implanted. There was a progressive demineralisation of about 16%. The suspicion of a typical combination with an encephalopathy due to dialysis did not confirm itself. A pseudocyst in the brain was found. The differential diagnosis to the hypercalcaemia-induced psychosis in the osteopathy due to dialysis is discussed. In a prophylactic application dihydrotachysterine proved favourable for avoidance of an osteopathy due to dialysis. Parallel to the clinical progressing of the osteopathy due to dialysis a progressive demineralisation could be demonstrated at the peripheral mineral contents of the bones. Extreme losses of minerals appeared from the 4th to the 59th month of dialysis from - 16% to - 37% and from the 22nd to the 87th month from plus 11% to minus 14% of the age-and-sex-specific normal values. Successful transplantations led to the stagnation of the progressive demineralisation, unsucessful transplantations increase them. The influence of the non-refined water for the production of dialysate by possible aluminium intoxications on the development of the osteopathy due to dialysis is discussed.

Dialysis-associated amyloid osteopathy--the radiological aspects
Schadmand, S., K. J. Klose, et al. (1991), Rofo 154(6): 610-3.
Abstract: Amongst the complications of dialysis, amyloid osteopathy is getting increasingly significant. It is due to deposition of beta 2-microglobulin. To determine the incidence and time of development of this complication, the skeletal radiographs of 185 patients undergoing dialysis, some for up to ten years, were analysed retrospectively. In about 10% of patients, the presence of beta 2-microglobulin osteopathy may be expected. The radiological features, sites of predilection and differential diagnosis of amyloid osteopathy and of other skeletal changes due to dialysis are discussed.

Dietetics, deficiency osteopathy & parathyroid adenoma.
Granjon, P., L. Perdrix, et al. (1959), Mars Chir 11(1): 130-6.

Diffuse condensing osteopathy
Coutant, G., J. P. Algayres, et al. (1997), Rev Med Interne 18(7): 582-3.

Diffuse plasmocytoma with the clinical aspects of generalized calciprivic osteopathy.
Kaumanns, H. and H. Rohkramer (1950), Arztl Wochensch 5(36): 699-702.

Digital hippocratism and hypertrophic pneumonic osteopathy; relations with bronchiectasis of childhood.
Jumon, H. (1951), Bull Med 65(10): 247-8.

Discussion remark on the paper of Breuel et al.: Osteoporosis diagnosis with a 125-I profile scanner in renal osteopathy. This J. 51,767(1973)
Borner, W., E. Moll, et al. (1974), Klin Wochenschr 52(11): 555-6.

Dry "osteopathy"
Steiner, O. (1967), Zahnarztl Mitt 57(2): 77-80.

Dynamic bone scintigraphy in the diagnosis of renal osteopathy
Sotornik, I., J. Pivonka, et al. (1994), Cas Lek Cesk 133(1): 15-9.
Abstract: A study was undertaken to assess types of RO by a dynamic modification of osteoscintigraphy 53 pts dialyzed for 27-75 mths, 19-52 yrs old were divided, according to histological bone pictures, into 4 groups: I) 11 pts with hyperparathyroidism, II) 12 pts with osteomalacia, III) 11 pts with mixed RO, IV) 11 pts were after parathyroidectomy (PTE) and 13 controls. Investigations: the rate of 99mTc-Sn-HEDP accumulation in the skeleton, skeletal/background radioactivity index both registered for 60 min. (parameters K and P), serum levels of C-PTH, bone isoenzyme of alkaline phosphatase (bALP), acid phosphatase (ACP), free hydroxyproline (S-Hypro). RESULTS: 1. compared to controls: elevations of K and all biochemical parameters, P in groups I and III (p < 0.01 - < 0.001) were found. 2. Group 1 was characterized by the highest values of all parameters compared to groups II and IV (p < 0.01). 3. Linear relationships were found between K and bALP (p < 0.01), P and bALP, ACP, S-Hypro (p < 0.01) in pts of groups I, II, III. 4. PTE in group IV was followed by a decrease in all parameters (p < 0.01) compared to values of the same pts in group I. Aluminum osteopathy was present in 2/3 of cases in group II showing the lowest values of all parameters. CONCLUSION: DBS is a sensitive method for assessing bone turnover rate according to the degree of skeletal uptake of radionuclide. In this manner it is possible to determine both the type of RO and it's further development in repeated measurements.

Dynamic osteopathy of the metatarsus in civil practice.
Cabot, J. R. and J. M. Vilaseca (1950), Rev Esp Reumatol 3(8): 539-57.

Dynamic osteopathy of the pubis
Losada, A. and E. Saldias (1968), Rev Med Chil 96(2): 110-4.

Early calcipenic osteopathy in the panoramic x-ray image of the maxillary and mandibular alveolar process of young adult alcoholics
Szanto, D., L. Bohatka, et al. (1990), Orv Hetil 131(42): 2313-6.
Abstract: The authors have examined 220 maxillary and mandibular panoramic roentgenograms of 55-55, all 110, between 21-34 years of age alcohol addict males and females with a complete dentitions and intact parodontium. In 19 per cent of patients developed osteoporomalacia, cystic rarefications and multiple pathologic microfractures of the alveolar spongy bone tissues. The calcipenic osteopathia was verified by the routine laboratory disorders of calcium and phosphor metabolisms, besides by the diminution of roentgenmorphometrical index of right 2nd metacarpus and tibia. The osteoporomalacia of alveolar parts preceded calcipenic osteopathia of all bones in 52 per cent of patients. A quantity of 25-50 g alcohol consumed daily would be resulting the calcipenic osteopathia after 3-5 years. Its development may be due to individual praedisposition influenced by nutritional, hormonal, genetic and hepatopancreatic factors.

Effect of 1,25-dihydroxycholecalciferol in renal osteopathy
Reutter, F. W., R. Sieber, et al. (1979), Schweiz Med Wochenschr 109(47): 1880-3.
Abstract: 9 patients with advanced renal failure and renal osteodystrophy documented by iliac crest biopsy were treated with 1,25-dihydroxycholecalciferol (average dose 0.53 micrograms per day) for 6 months. Under 1,25-DHCC there was a statistically significant increase in serum calcium and decrease in serum alkaline phosphatase and immune parathyroid hormone. Histomorphometric evaluation of posttreatment bone biopsies showed reduction of osteoclastic resorption and endosteal fibrosis. Osteoid volume decreased in most cases. In 3 patients with predominant fibroosteoclasia, bone turnover practically normalized. Bone mineral content of the radius (photoabsorptiometry) did not change with treatment. Transient hypercalcemia occurred in 5 patients and was easily corrected by adjustment of 1,25-DHCC dosage.

Effect of bone diseases on the morphology of the joints (lunatummalacia and sacroiliacal pseudolitation in renal osteopathy)
Dihlmann, W. (1974), Verh Dtsch Ges Rheumatol 3(0): 164-7.

Effect of cancerogenic extracts producing P. Marie's pulmonary hypertrophic osteopathy on distrophies of various origin in growing guinea-pig.
Thiers, H., M. Berard, et al. (1951), Lyon Med 184(14): 229-33.

Effect of dihydrotachysterol in the treatment and prevention of uremic osteopathy in children
Sieniawska, M. and D. Bialasik (1981), Pediatr Pol 56(7): 733-41.

Effect of ultraviolet irradiation on renal osteopathy in patients in the chronic hemodialysis program
Koall, W., H. Klette, et al. (1982), Z Gesamte Inn Med 37(23): 805-9.
Abstract: Under influence of the ultraviolet radiation the formerly lowered 25-hydroxycholecalciferol (25-OH-CC) level increases in persons with healthy kidneys. Such investigations were not yet carried out in patients undergoing dialysis. Since the insufficiency of active vitamin-D-metabolites plays an essential role in the development of the renal osteopathy, since 1978 in 13 patients undergoing dialysis a regular ultraviolet radiation has been performed, in order to stimulate the cutaneous vitamin-D-production. The time of observation was 31.7 +/- 14.3 months. Deionized water served for the production of dialysate. The calcium content was about 3.5 +/- 3.8 mval/l. The patients had very rarely bone and joint complaints. Severe clinical complications of renal osteopathy developed only in one female patient in the 3rd year of dialysis with a fracture of the neck of the femur as well as in a 2nd patient after transplantation of a kidney with permanently progressing demineralization and spondylitis. Controls of the courses showed only in 18.2% a progressing loss of the peripheral mineral content of the bones. The alkaline phosphatase was not increased, the alkaline bone phosphatase appeared with low and not provable activities. A suppression of the secondary hyperparathyroidism could not be proved. Parathormone was increased with 2.30 +/- 1.90 micrograms/l. The 25-OH-CC-levels were normal or slightly increased with 39.1 +/- 12.4 micrograms/l, whereas they were essentially lower in a comparative group without ultraviolet radiation. Therefore in connection with the very low rate of complications of the renal osteopathy with normalized 25-OH-CC-levels new therapeutic possibilities were the result in patients undergoing dialysis after ultraviolet radiation. The increasing importance consists also in the fact that 90% of the human vitamin-D-need are supplied via skin and it was proved by animal experiments that also after bilateral nephrectomy the formation of the active vitamin-D-metabolite 1,25-dihydroxycholecalciferol is possible by photosynthesis.

Effect of varying doses of vitamin D 3 on the nature of the osteopathy induced by lack of calcium in the growing rat
Mathieu, H., M. Laval-Jeantet, et al. (1966), Pathol Biol 14(23): 1117-34.


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